Cytokeratin 5/KRT5 Gene Sequence, Family, Fuction and Expression Information

Cytokeratin 5/KRT5 cDNA / Gene Overview

KRT5 gene / cDNA is a protein-coding gene which located on 12q13.13. The KRT5 gene is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.88 organisms have orthologs with human gene KRT5.

Cytokeratin 5/KRT5 cDNA / Gene Function

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

Cytokeratin 5/KRT5 cDNA / Gene Sequence

LOCUS
LOCUS NM_000424 2320 bp mRNA linear PRI 11-JUN-2018
DEFINITION
Homo sapiens keratin 5 (KRT5), mRNA.
ACCESSION
NM_000424
VERSION
NM_000424.3

This sequence information is just for reference only.

Cytokeratin 5/KRT5 cDNA / Gene Alias

  • KRT5A

Cytokeratin 5/KRT5 cDNA / Gene Expression

Biased expression in skin (RPKM 2610.9) and esophagus (RPKM 1766.7)