FAM175B Information: FAM175B Protein, FAM175B Antibody and FAM175B Gene

FAM175B Gene family

FAM175B Protein

FAM175B protein function

Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148).

FAM175B protein expression

Tissue specificity

Detected in heart muscle (at protein level). Detected in heart and muscle, and at much lower levels in brain (PubMed:21195082).

Induction

Up-regulated in response to DNA damage (PubMed:25283148). Up-regulated in myocardial infarction area (at protein level) (PubMed:21195082).

FAM175B protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    415.00
  • Mass (KDa)
    46.00

FAM175B Antibody

There are 1 FAM175B antibodies which are validated in multiple tissues with various applications, including WB, ICC/IF. There are 1 FAM175B antibody for WB, 1 FAM175B antibody for ICC/IF. Among all these FAM175B antibodies, there are 1 anti-FAM175B rabbit polyclonal antibodies . All the FAM175B anbodies are produced in house and all are in stock. FAM175B antibody customerized service is available.

FAM175B Gene

ABRAXAS2 cDNA / gene is a gene with protein product which located on 10q26.13. The ABRAXAS2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. 237 organisms have orthologs with human gene ABRAXAS2.