FGF12 Protein Overview: Sequence, Structure, Function and Protein Interaction

FGF12 Protein Overview

Smallwood et al. (1996) identified and characterized 4 novel members of the fibroblast growth factor (FGF) family, including FGF12, which they referred to as fibroblast growth factor homologous factors (FHFs). The genes were identified by a combination of random cDNA sequencing, database searches, and degenerate PCR. Pairwise comparisons between the 4 FHFs show between 58% and 71% amino acid sequence identity, but each FHF shows less than 30% identity when compared with other FGFs. Like FGF1 (131220) and FGF2 (134920), the FHFs lack a classic signal sequence and contain clusters of basic residues that can act as nuclear localization signals. In transiently transfected 293 cells, FHF1 accumulates in the nucleus and is not secreted.

FGF12 protein family

Belongs to the heparin-binding growth factors family.

FGF12 protein name

Recommended name
Fibroblast growth factor 12
Short name
FHF1, fibroblast growth factor 12B, fibroblast growth factor FGF-12b, fibroblast growth factor homologous factor 1, myocyte-activating factor
Alternative name
Fibroblast growth factor homologous factor 1 Myocyte-activating factor

FGF12 Protein Sequence

Species Human FGF12 protein
Length 243
Mass (Da) 27399
Sequence Human FGF12 protein sequence
Species Mouse FGF12 protein
Length 243
Mass (Da) 27399
Sequence Mouse FGF12 protein sequence
Species Rat FGF12 protein
Length 243
Mass (Da) 27399
Sequence Rat FGF12 protein sequence

FGF12 Protein Molecular Weight & PI

Fibroblast growth factor 12 (FGF-12) (Fibroblast growth factor homologous factor 1) (FHF-1) (Myocyte-activating factor) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-243 Fibroblast growth factor 12.

Molecular weight (Da)


Theoretical pI


FGF12 Protein Structure

Crystal structure of human FHF1b (FGF12b)
2003-07-22   Released:  2003-08-05
Deposition Author(s)
Olsen, S.K., Garbi, M., Zampieri, N., Eliseenkova, A.V., Ornitz, D.M., Goldfarb, M., Mohammadi, M.
Homo sapiens
Expression System
Escherichia coli BL21
Experimental Data Snapshot
1.7000 Å
R-Value Free
R-Value Work
1Q1U From PDB

Human FGF12 protein Secondary structure

FGF12 Protein Interaction

Recombinant FGF12 Protein Feature

FGF12 Protein, Canine, Recombinant

High Purity
> 90 % as determined by SDS-PAGE
Low Endotoxin
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