FGFRL1 Gene Sequence, Family, Fuction and Expression Information
FGFRL1 cDNA / Gene Overview
FGFRL1 gene / cDNA is a protein-coding gene which located on 4p16.3. The FGFRL1 gene is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, and frog.225 organisms have orthologs with human gene FGFRL1.
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
FGFRL1 cDNA / Gene Sequence
LOCUS NM_021923 3105 bp mRNA linear PRI 23-JUN-2018
Homo sapiens fibroblast growth factor receptor like 1 (FGFRL1), transcript variant 3, mRNA.
This sequence information is just for reference only.