FGFRL1 Gene Sequence, Family, Fuction and Expression Information

FGFRL1 cDNA / Gene Overview

FGFRL1 gene / cDNA is a protein-coding gene which located on 4p16.3. The FGFRL1 gene is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, and frog.225 organisms have orthologs with human gene FGFRL1.

FGFRL1 cDNA / Gene Function

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

FGFRL1 cDNA / Gene Sequence

LOCUS
LOCUS NM_021923 3105 bp mRNA linear PRI 23-JUN-2018
DEFINITION
Homo sapiens fibroblast growth factor receptor like 1 (FGFRL1), transcript variant 3, mRNA.
ACCESSION
NM_021923
VERSION
NM_021923.3

This sequence information is just for reference only.

FGFRL1 Family & Reagents

FGFRL1 Gene family reagents (I-set domain containing)

Approved Symbol Reagent list
CNTN6
MERTK
ROR2
KIRREL2
WFIKKN2
FGFR4
FGFR3
VCAM1
IGFBP7
NPTN
Approved Symbol Reagent list
PDGFRA
PDGFRB
FGFR2
KIRREL1
MUSK
JAM2
IL1RL1
NEGR1
UNC5B
ROBO4

FGFRL1 Gene family reagents (Ig-like cell adhesion molecule family)

Approved Symbol Reagent list
CD96
NECTIN1
JAM2
NECTIN3
ICAM4
ICAM3
F11R
ICAM2
NECTIN2
UNC5B
Approved Symbol Reagent list
VCAM1
CNTN1
IZUMO1
CNTN3
CNTN2
PVR
SIRPA
SLAMF6
CADM3
PECAM1

FGFRL1 cDNA / Gene Expression

Ubiquitous expression in thyroid (RPKM 21.2), fat (RPKM 15.4) and 25 other tissues