Fibrinogen gamma chain/FGG Information: Fibrinogen gamma chain/FGG Protein, Fibrinogen gamma chain/FGG Antibody and Fibrinogen gamma chain/FGG Gene

Fibrinogen gamma chain/FGG Gene family

Fibrinogen gamma chain/FGG Protein

Fibrinogen gamma chain/FGG protein function

Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.

Fibrinogen gamma chain/FGG protein expression

Tissue specificity

Detected in blood plasma (at protein level).

Fibrinogen gamma chain/FGG protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    453.00
  • Mass (KDa)
    51.00

Fibrinogen gamma chain/FGG Gene

FGG gene / cDNA is a protein-coding gene which located on 4q32.1. The FGG gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.236 organisms have orthologs with human gene FGG.