Fibrinogen gamma chain/FGG Gene Sequence, Family, Fuction and Expression Information
Fibrinogen gamma chain/FGG cDNA / Gene Overview
FGG gene / cDNA is a protein-coding gene which located on 4q32.1. The FGG gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.236 organisms have orthologs with human gene FGG.
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Fibrinogen gamma chain/FGG cDNA / Gene Sequence
LOCUS NM_021870 1763 bp mRNA linear PRI 29-JUL-2018
Homo sapiens fibrinogen gamma chain (FGG), transcript variant gamma-B, mRNA.
This sequence information is just for reference only.