Fibrinogen gamma chain/FGG Gene Sequence, Family, Fuction and Expression Information

Fibrinogen gamma chain/FGG cDNA / Gene Overview

FGG gene / cDNA is a protein-coding gene which located on 4q32.1. The FGG gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.236 organisms have orthologs with human gene FGG.

Fibrinogen gamma chain/FGG cDNA / Gene Function

The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

Fibrinogen gamma chain/FGG cDNA / Gene Sequence

LOCUS
LOCUS NM_021870 1763 bp mRNA linear PRI 29-JUL-2018
DEFINITION
Homo sapiens fibrinogen gamma chain (FGG), transcript variant gamma-B, mRNA.
ACCESSION
NM_021870
VERSION
NM_021870.2

This sequence information is just for reference only.

Fibrinogen gamma chain/FGG Family & Reagents

Fibrinogen gamma chain/FGG Gene family reagents (Endogenous ligands)

Approved Symbol Reagent list
RAC2
ARF1
PTN
GAL
ICOSLG
NTS
CCL20
KNG1
Spp1
ICAM1
Approved Symbol Reagent list
LGALS3
RSPO1
CCL2
CXCL12
AGRP
FASLG
Fgf8
IL1RN
BMP5
FLT3LG

Fibrinogen gamma chain/FGG Gene family reagents (Fibrinogen C domain containing)

Approved Symbol Reagent list
ANGPT1
ANGPT4
ANGPTL2
ANGPTL4
ANGPTL7
FGL1
Approved Symbol Reagent list
ANGPT2
ANGPTL1
ANGPTL3
ANGPTL5
FCN1
   

Fibrinogen gamma chain/FGG cDNA / Gene Expression

Restricted expression toward liver (RPKM 3614.5)