GLA/alpha-Galactosidase A Protein Overview: Sequence, Structure, Function and Protein Interaction

GLA/alpha-Galactosidase A Protein Overview

The GLA gene encodes alpha-galactosidase (GLA; EC, a lysosomal hydrolase.

GLA/alpha-Galactosidase A protein family

Belongs to the glycosyl hydrolase 27 family.

GLA/alpha-Galactosidase A protein name

Recommended name
Alpha-galactosidase A
Alternative name
Alpha-D-galactosidase A Alpha-D-galactoside galactohydrolase Melibiase INN: Agalsidase

GLA/alpha-Galactosidase A Protein Sequence

Species Human GLA/alpha-Galactosidase A protein
Length 429
Mass (Da) 48767
Sequence Human GLA/alpha-Galactosidase A protein sequence
Species Mouse GLA/alpha-Galactosidase A protein
Length 419
Mass (Da) 47643
Sequence Mouse GLA/alpha-Galactosidase A protein sequence
Mass (Da)

GLA/alpha-Galactosidase A Protein Molecular Weight & PI

Alpha-galactosidase A precursor (EC (Alpha-D-galactosidase A) (Alpha-D-galactoside galactohydrolase) (Melibiase) (Agalsidase) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 32-429 Alpha-galactosidase A.

Molecular weight (Da)


Theoretical pI


GLA/alpha-Galactosidase A Protein Interaction

Recombinant GLA/alpha-Galactosidase A Protein Feature

GLA/alpha-Galactosidase A Protein, Human, Recombinant (His Tag)

High Purity
> 97 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

Recombinant GLA/alpha-Galactosidase A protein citations

Comparison of intracellular and secretion-based strategies for production of human ¿-galactosidase A in the filamentous fungus Trichoderma reesei
Smith, W;Jäntti, J;Oja, M;Saloheimo, M;
BMC Biotechnol.
Substrate and Substrate-Mimetic Chaperone Binding Sites in Human α-Galactosidase A Revealed by Affinity-Mass Spectrometry
Moise, A;Maeser, S;Rawer, S;Eggers, F;Murphy, M;Bornheim, J;Przybylski, M;
J. Am. Soc. Mass Spectrom.
Antibody Epitope of human α-Galactosidase A revealed by affinity-mass spectrometry: A basis for reversing immunoreactivity in enzyme replacement therapy of Fabry's Disease
Przybylski, M;

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