Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking).
GPR114 protein expression
Expressed in immune cells. Primarily found in granulocytes. Found in eosinophils.
ADGRG5 gene / cDNA is a protein-coding gene which located on 16q21. The ADGRG5 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.147 organisms have orthologs with human gene ADGRG5.