HSP60 Information: HSP60 Protein, HSP60 Antibody and HSP60 Gene

HSP60 Gene family

HSP60 Protein

HSP60 protein function

Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}.

HSP60 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (KDa)

HSP60 Antibody

There are 3 HSP60 antibodies which are validated in multiple tissues with various applications, including WB, ICC/IF, IP, IHC-P, ELISA. There are 3 HSP60 antibody for WB, 2 HSP60 antibody for ICC/IF, 3 HSP60 antibody for IP, 2 HSP60 antibody for IHC-P, 1 HSP60 antibody for ELISA. Among all these HSP60 antibodies, there are 3 anti-HSP60 rabbit polyclonal antibodies . All the HSP60 anbodies are produced in house and all are in stock. HSP60 antibody customerized service is available.

HSP60 Gene

HSPD1 gene / cDNA is a protein-coding gene which located on 2q33.1. The HSPD1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.239 organisms have orthologs with human gene HSPD1.