HSP60 Protein Overview: Sequence, Structure, Function and Protein Interaction

HSP60 Protein Overview

It had long been assumed that all information necessary for proper folding of proteins and their assembly into oligomeric complexes was contained within the primary sequence of the polypeptides and that no catalyst or other accessory proteins were involved in this process. However, this basic tenet of biochemistry was challenged by the discovery of chaperonins, which are involved in the folding and assembly of a number of different proteins (Cheng et al., 1989; Ellis, 1990; Rothman, 1989). Members of the chaperonin family include the GroEL protein of E. coli and HSP60, a protein present in eukaryotic cell mitochondria. In both prokaryotic and eukaryotic systems, synthesis of these proteins is induced in response to stresses, such as heat shock (Venner et al., 1990).

HSP60 protein family

Belongs to the chaperonin (HSP60) family.

HSP60 protein name

Recommended name
60 kDa heat shock protein, mitochondrial
Short name
CPN60||Heat shock protein 60||HSP-60||Hsp60
GroEL, HSP60
Alternative name
60 kDa chaperonin Chaperonin 60 Heat shock protein 60 HuCHA60 Mitochondrial matrix protein P1 P60 lymphocyte protein

HSP60 Gene family protein

Approved symbol Common name
HSPE1 Cpn10/HSPE1 protein, recombinant

HSP60 Protein Sequence

Species Human HSP60 protein
Length 573
Mass (Da) 61055
Sequence Human HSP60 protein sequence
Species Mouse HSP60 protein
Length 573
Mass (Da) 60955
Sequence Mouse HSP60 protein sequence
Species Rat HSP60 protein
Length 573
Mass (Da) 60955
Sequence Rat HSP60 protein sequence

HSP60 Protein Molecular Weight & PI

60 kDa heat shock protein, mitochondrial precursor (EC (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 27-573 60 kDa heat shock protein, mitochondrial.

Molecular weight (Da)


Theoretical pI


HSP60 Protein Structure

Crystal structure of the human mitochondrial chaperonin symmetrical 'football' complex
2014-05-10   Released:  2015-04-29
Deposition Author(s)
Frolow, F., Azem, A., Nisemblat, S.
Homo sapiens
Expression System
Escherichia coli-Thermus thermophilus shuttle vector pTRH1T
Experimental Data Snapshot
3.1500 Å
R-Value Free
R-Value Work
4PJ1 From PDB

Human HSP60 protein Secondary structure

HSP60 Protein Interaction

Recombinant HSP60 Protein Feature

HSP60 Protein, Human, Recombinant (His & GST Tag)

High Purity
> 90 % as determined by SDS-PAGE
Low Endotoxin
Please contact us for more information.

Recombinant HSP60 protein citations

Salivary auto-antibodies as noninvasive diagnostic markers of oral cavity squamous cell carcinoma
Wu, CC;Chang, YT;Chang, KP;Liu, YL;Liu, HP;Lee, IL;Yu, JS;Chiang, WF;
Cancer Epidemiol. Biomarkers Prev.
Annexin A2 as a target endothelial cell membrane autoantigen in Behçet's disease
Chen, P;Yan, H;Tian, Y;Xun, Y;Shi, L;Bao, R;Zhang, H;Chen, G;Yang, C;Sun, S;Wang, Y;Liu, L;Zhou, Y;Zhang, C;Wang, X;Wen, Y;Bian, Y;Du, H;
Sci Rep

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