ICAM5 Protein Overview: Sequence, Structure, Function and Protein Interaction

ICAM5 Protein Overview

Yoshihara and Mori (1994) reviewed information on a brain segment-specific cell adhesion molecule, telencephalin. Neuronal surface membranes are polarized into axonal membrane and soma-dendritic membrane. Telencephalin was the first described example of a dendritic cell adhesion molecule. A large number of axonal cell adhesion molecules have been identified and categorized into 3 different groups: the Ig superfamily, the cadherin superfamily (see 192090), and the integrin family (see 135630). Telencephalin was discovered through production of a library of monoclonal antibodies (mAbs) against the dendrodendritic synaptosomal fraction of the rabbit olfactory bulb. By immunohistochemical studies, 1 mAb selectively labeled gray matter of all regions in the telencephalon but no brain segments more caudal to the telencephalon. The 130-kD membrane glycoprotein recognized by this mAb was thus designated telencephalin. Yoshihara et al. (1994) cloned the rabbit TLCN cDNA and demonstrated that rabbit TLCN is a type 1 integral membrane protein with a 29-amino acid signal peptide, a 792-amino acid extracellular region, a 30-amino acid transmembrane region, and a 61-amino acid cytoplasmic region. The extracellular portion of TLCN contains 9 tandem repeats of C2-type immunoglobulin-like domains with intrachain disulfide bonds. Several of these domains of mouse TLCN share high amino acid identity with the corresponding domains of ICAM3 (146631). Yoshihara and Mori (1994) suggested that telencephalin is involved in signaling specific subsets of growing axons to make proper synaptic connections. Mizuno et al. (1997) isolated cDNA encoding human telencephalin. The 924-amino acid polypeptide comprises an N-terminal signal peptide, an extracellular region with 9 Ig-like domains, a single transmembrane region, and a C-terminal cytoplasmic tail.

ICAM5 protein family

Belongs to the immunoglobulin superfamily. ICAM family.

ICAM5 protein name

Recommended name
Intercellular adhesion molecule 5
Short name
telencephalin, TLN
Alternative name

ICAM5 Gene family protein

ICAM5 Protein Sequence

Species Human ICAM5 protein
Length 924
Mass (Da) 97116
Sequence Human ICAM5 protein sequence
Species Mouse ICAM5 protein
Length 917
Mass (Da) 96946
Sequence Mouse ICAM5 protein sequence
Mass (Da)

ICAM5 Protein Molecular Weight & PI

Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 32-924 Intercellular adhesion molecule 5.

Molecular weight (Da)


Theoretical pI


ICAM5 Protein Structure

Crystal Structure of ICAM-5 D1-D4 ectodomain fragment, Space Group P4322
2014-01-19   Released:  2014-07-16
Deposition Author(s)
Recacha, R., Jimenez, D., Tian, L., Barredo, R., Ghamberg, C., Casasnovas, J.M.
Homo sapiens
Expression System
Homo sapiens
Experimental Data Snapshot
3.7000 Å
R-Value Free
R-Value Work

Human ICAM5 protein Secondary structure

ICAM5 Protein Interaction

Recombinant ICAM5 Protein Feature

ICAM5 Protein, Human, Recombinant (ECD, His Tag)

High Purity
> 90 % as determined by SDS-PAGE.
Low Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.

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