IDO Information: IDO Protein, IDO Antibody and IDO Gene

IDO Protein

IDO protein function

Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885). {ECO:0000269|PubMed:14502282, ECO:0000269|PubMed:17671174, ECO:0000303|PubMed:23103127, ECO:0000303|PubMed:25157255, ECO:0000303|PubMed:25691885}.

IDO protein expression

Tissue specificity

Expressed in mature dendritic cells located in lymphoid organs (including lymph nodes, spleen, tonsils, Peyers's patches, the gut lamina propria, and the thymic medulla), in some epithelial cells of the female genital tract, as well as in endothelial cells of term placenta and in lung parenchyma (PubMed:25691885). Weakly or not expressed in most normal tissues, but mostly inducible in most tissues (PubMed:25691885). Expressed in more than 50% of tumors, either by tumoral, stromal, or endothelial cells (expression in tumor is associated with a worse clinical outcome) (PubMed:18418598). Not overexpressed in tumor-draining lymph nodes (PubMed:26155395, PubMed:25691885).

Induction

By IFNG/IFN-gamma in most cells (PubMed:2109605, PubMed:1907934). Exogenous inflammatory stimuli induce the expression of IDO1 in antigen-presenting cells such as dendritic cells, macrophages and B-cells (PubMed:25157255).

IDO protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    403.00
  • Mass (KDa)
    45.00

IDO Antibody

There are 6 IDO antibodies which are validated in multiple tissues with various applications, including ELISA, IHC-P, WB, ICC/IF, IP. There are 4 IDO antibody for ELISA, 2 IDO antibody for IHC-P, 3 IDO antibody for WB, 3 IDO antibody for ICC/IF, 1 IDO antibody for IP. Among all these IDO antibodies, there are 6 anti-IDO rabbit polyclonal antibodies . All the IDO anbodies are produced in house and all are in stock. IDO antibody customerized service is available.

IDO Gene

IDO1 gene / cDNA is a protein-coding gene which located on 8p11.21. The IDO1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, S.cerevisiae, E.gossypii, M.oryzae, and N.crassa.114 organisms have orthologs with human gene IDO1.