IDO Gene Sequence, Family, Fuction and Expression Information
IDO cDNA / Gene Overview
IDO1 gene / cDNA is a protein-coding gene which located on 8p11.21. The IDO1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, S.cerevisiae, E.gossypii, M.oryzae, and N.crassa.114 organisms have orthologs with human gene IDO1.
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
IDO cDNA / Gene Sequence
LOCUS NM_002164 1944 bp mRNA linear PRI 05-AUG-2018
Homo sapiens indoleamine 2,3-dioxygenase 1 (IDO1), mRNA.
This sequence information is just for reference only.
IDO cDNA / Gene Expression
Biased expression in placenta (RPKM 49.9), lymph node (RPKM 25.9) and 9 other tissues