IDO Protein Overview: Sequence, Structure, Function and Protein Interaction

IDO Protein Overview

Gamma-interferon (IFNG; 147570) has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and Chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase (INDO; EC 1.13.11.52). This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to N-formyl-kynurenine.

IDO protein family

Belongs to the indoleamine 2,3-dioxygenase family.

IDO protein name

Recommended name
Indoleamine 2,3-dioxygenase 1
Short name
IDO-1
Alternative name
Indoleamine-pyrrole 2,3-dioxygenase

IDO Protein Sequence

Species Human IDO protein
Length 403
Mass (Da) 45326
Sequence Human IDO protein sequence
Species Mouse IDO protein
Length 407
Mass (Da) 45641
Sequence Mouse IDO protein sequence
Species Rat IDO protein
Length 407
Mass (Da) 45831
Sequence Rat IDO protein sequence

IDO Protein Molecular Weight & PI

Indoleamine 2,3-dioxygenase 1 (EC 1.13.11.52) (IDO-1) (Indoleamine-pyrrole 2,3-dioxygenase) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-403 Indoleamine 2,3-dioxygenase 1.

Molecular weight (Da)

45326.28

Theoretical pI

6.87

IDO Protein Structure

IDO1/BMS-978587 crystal structure
Deposited
2017-09-13   Released:  2018-03-21
Deposition Author(s)
Lewis, H.A.
Organism(s)
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.7550 Å
R-Value Free
0.272
R-Value Work
0.195
6AZV From PDB

Human IDO protein Secondary structure

IDO Protein Interaction

Recombinant IDO Protein Feature

IDO Protein, Human, Recombinant

High Purity
> 85 % as determined by SDS-PAGE
Low Endotoxin
Please contact us for more information.
High Activity
Measured by its ability to oxidize L-tryptophan to N-formylk-ynurenine. The specific activity is > 500 pmoles/min/μg.

Recombinant IDO protein citations

Title
Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome
Year
2017
Author
Ren, Y;Su, Y;Sun, L;He, S;Meng, L;Liao, D;Liu, X;Ma, Y;Liu, C;Li, S;Ruan, H;Lei, X;Wang, X;Zhang, Z;
Journal
J. Med. Chem

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