IL-15 Gene Sequence, Family, Fuction and Expression Information

IL-15 cDNA / Gene Overview

IL15 gene / cDNA is a protein-coding gene which located on 4q31.21. The IL15 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.202 organisms have orthologs with human gene IL15.

IL-15 cDNA / Gene Function

The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]

IL-15 cDNA / Gene Sequence

LOCUS
LOCUS NM_172175 2333 bp mRNA linear PRI 05-AUG-2018
DEFINITION
Homo sapiens interleukin 15 (IL15), transcript variant 2, mRNA.
ACCESSION
NM_172175
VERSION
NM_172175.2

This sequence information is just for reference only.

IL-15 Family & Reagents

Gene family

IL-15 Gene family reagents (Interleukins)

Approved Symbol Reagent list
CXCL8
IL21
IL10
IL22
IL12A
IL37
IL17B
IL17F
IL1RN
IL13
Approved Symbol Reagent list
IL18
IL17A
IL2
IL1B
IL25
IL27
IL3
IL36B
IL36G
IL36A

IL-15 cDNA / Gene Alias

  • IL-15
  • MGC9721

IL-15 cDNA / Gene Expression

Ubiquitous expression in spleen (RPKM 3.4), thyroid (RPKM 2.4) and 23 other tissues