IL1RAPL1 Protein Overview: Sequence, Structure, Function and Protein Interaction

IL1RAPL1 Protein Overview

The IL1RAPL1 gene encodes a protein with high levels of expression in brain neurons. It participates in the regulation of neurite outgrowth and exocytosis via its interaction with neuronal calcium sensors and the downregulation of calcium channels (Bahi et al., 2003; Gambino et al., 2007). These actions appear to regulate synaptic formation and modulation of synaptic transmission (Piton et al., 2008).

IL1RAPL1 protein family

Belongs to the interleukin-1 receptor family.

IL1RAPL1 protein name

Recommended name
Interleukin-1 receptor accessory protein-like 1
Short name
Alternative name
Oligophrenin-4 Three immunoglobulin domain-containing IL-1 receptor-related 2 X-linked interleukin-1 receptor accessory protein-like 1

IL1RAPL1 Gene family protein

X-linked mental retardation

IL1RAPL1 Protein Sequence

Species Human IL1RAPL1 protein
Length 696
Mass (Da) 79969
Sequence Human IL1RAPL1 protein sequence
Species Mouse IL1RAPL1 protein
Length 695
Mass (Da) 79630
Sequence Mouse IL1RAPL1 protein sequence
Species Rat IL1RAPL1 protein
Length 696
Mass (Da) 79771
Sequence Rat IL1RAPL1 protein sequence

IL1RAPL1 Protein Molecular Weight & PI

Interleukin-1 receptor accessory protein-like 1 precursor (IL-1-RAPL-1) (IL-1RAPL-1) (IL1RAPL-1) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2) (X-linked interleukin-1 receptor accessory protein-like 1) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 19-696 Interleukin-1 receptor accessory protein-

Molecular weight (Da)


Theoretical pI


IL1RAPL1 Protein Structure

Crystal structure of the Toll/interleukin-1 receptor (TIR) domain of human IL-1RAPL
2004-04-26   Released:  2005-02-08
Deposition Author(s)
Khan, J.A., Tong, L.
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
2.3000 Å
R-Value Free
R-Value Work
1T3G From PDB

Human IL1RAPL1 protein Secondary structure

IL1RAPL1 Protein Interaction

Recombinant IL1RAPL1 Protein Feature

IL1RAPL1 Protein, Human, Recombinant (hFc Tag)

High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
Measured by its ability to bind biotinylated human IL1α (Cat:10128-HNCH) in functional ELISA.

Recombinant IL1RAPL1 protein citations

Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses
Mora, J;Schlemmer, A;Wittig, I;Richter, F;Putyrski, M;Frank, AC;Han, Y;Jung, M;Ernst, A;Weigert, A;Brüne, B;
J Mol Cell Biol

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