Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).
KAT2/AADAT protein expression
Higher expression in the liver. Also found in heart, brain, kidney, pancreas, prostate, testis and ovary.
AADAT cDNA / gene is a gene with protein product which located on 4q33. The AADAT gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, M.oryzae, and frog. 230 organisms have orthologs with human gene AADAT.