KDM3A Information: KDM3A Protein, KDM3A Antibody and KDM3A Gene

KDM3A Gene family

KDM3A Protein

KDM3A protein function

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. {ECO:0000269|PubMed:16603237, ECO:0000269|PubMed:28262558}.

KDM3A protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    1,321.00
  • Mass (KDa)
    147.00

KDM3A Antibody

There are 1 KDM3A antibodies which are validated in multiple tissues with various applications, including WB, ICC/IF. There are 1 KDM3A antibody for WB, 1 KDM3A antibody for ICC/IF. Among all these KDM3A antibodies, there are 1 anti-KDM3A rabbit polyclonal antibodies . All the KDM3A anbodies are produced in house and all are in stock. KDM3A antibody customerized service is available.

KDM3A Gene

KDM3A gene / cDNA is a protein-coding gene which located on 2p11.2. The KDM3A gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.190 organisms have orthologs with human gene KDM3A.