KRAS Protein Overview: Sequence, Structure, Function and Protein Interaction

KRAS Protein Overview

ONCOGENE KRAS1, INCLUDED; KRAS1, INCLUDEDKIRSTEN RAS1, INCLUDED; RASK1, INCLUDED

KRAS protein family

Belongs to the small GTPase superfamily. Ras family.

KRAS protein name

Recommended name
GTPase KRas
Aliases
KRAS1
Alternative name
K-Ras 2 Ki-Ras c-K-ras c-Ki-ras GTPase KRas, N-terminally processed

KRAS Gene family protein

KRAS Protein Sequence

Species Human KRAS protein
Length 189
Mass (Da) 21656
Sequence Human KRAS protein sequence
Species Mouse KRAS protein
Length 189
Mass (Da) 21656
Sequence Mouse KRAS protein sequence
Species Rat KRAS protein
Length 189
Mass (Da) 21656
Sequence Rat KRAS protein sequence

KRAS Protein Molecular Weight & PI

GTPase KRas precursor (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Contains: GTPase KRas, N-terminally processed] Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-186 GTPase KRas.

Molecular weight (Da)

21298.32

Theoretical pI

6.33

KRAS Protein Structure

Crystal Structure of human KRAS G12D mutant in complex with GDPNP
Deposited
2017-02-13   Released:  2017-03-22
Deposition Author(s)
Huang, C.S., Kaplan, A., Stockwell, B.R., Tong, L.
Organism(s)
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
1.9400 Å
R-Value Free
0.238
R-Value Work
0.177
5USJ From PDB

Human KRAS protein Secondary structure

KRAS Protein Interaction

Recombinant KRAS Protein Feature

Human KRAS / K-Ras (G12D & Q61H) Protein (His Tag)

High Purity
> 85 % as determined by SDS-PAGE
Low Endotoxin
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