LIF Gene Sequence, Family, Fuction and Expression Information
LIF cDNA / Gene Overview
LIF gene / cDNA is a protein-coding gene which located on 22q12.2. The LIF gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.171 organisms have orthologs with human gene LIF.
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
LIF cDNA / Gene Sequence
LOCUS NM_002309 3987 bp mRNA linear PRI 25-JUN-2018
Homo sapiens LIF, interleukin 6 family cytokine (LIF), transcript variant 1, mRNA.
This sequence information is just for reference only.