MMP13 Information: MMP13 Protein, MMP13 Antibody and MMP13 Gene

MMP13 Gene family

MMP13 Protein

MMP13 protein function

Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion. {ECO:0000269|PubMed:16167086, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:19615667, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:8207000, ECO:0000269|PubMed:8576151, ECO:0000269|PubMed:8603731, ECO:0000269|PubMed:8663255, ECO:0000269|PubMed:9065415}.

MMP13 protein expression

Tissue specificity

Detected in fetal cartilage and calvaria, in chondrocytes of hypertrophic cartilage in vertebrae and in the dorsal end of ribs undergoing ossification, as well as in osteoblasts and periosteal cells below the inner periosteal region of ossified ribs. Detected in chondrocytes from in joint cartilage that have been treated with TNF and IL1B, but not in untreated chondrocytes. Detected in T lymphocytes. Detected in breast carcinoma tissue.

Induction

Up-regulated by TNF and IL1B.

MMP13 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    471.00
  • Mass (KDa)
    53.00

MMP13 Antibody

There are 3 MMP13 antibodies which are validated in multiple tissues with various applications, including IHC-P, ICC/IF, WB. There are 3 MMP13 antibody for IHC-P, 1 MMP13 antibody for ICC/IF, 1 MMP13 antibody for WB. Among all these MMP13 antibodies, there are 3 anti-MMP13 rabbit polyclonal antibodies . All the MMP13 anbodies are produced in house and all are in stock. MMP13 antibody customerized service is available.

MMP13 Gene

MMP13 gene / cDNA is a protein-coding gene which located on 11q22.2. The MMP13 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, and frog.162 organisms have orthologs with human gene MMP13.