MUC1 Protein Overview: Sequence, Structure, Function and Protein Interaction

MUC1 Protein Overview

Mucins are heavily glycosylated proteins thought to function in the protection of epithelial surfaces. Secreted and transmembrane mucins form a protective mucous barrier, and transmembrane mucins may also function in signaling the presence of adverse conditions in the extracellular environment. MUC1 is a transmembrane mucin normally expressed on the apical borders of secretory epithelial cells (Yin et al., 2003).

MUC1 protein name

Recommended name
Mucin-1
Short name
MUC-1||CA 15-3||KL-6||PUM||PEM||EMA
Aliases
ADMCKD, ADMCKD1, CD227, MCD, MCKD, PEM
Alternative name
Breast carcinoma-associated antigen DF3 Cancer antigen 15-3 Carcinoma-associated mucin Episialin H23AG Krebs von den Lungen-6 PEMT Peanut-reactive urinary mucin Polymorphic epithelial mucin Tumor-associated epithelial membrane antigen Tumor-associated mucin CD_antigen: CD227 Mucin-1 subunit alpha Mucin-1 subunit beta

MUC1 Protein Sequence

Species Human MUC1 protein
Length 1255
Mass (Da) 122102
Sequence Human MUC1 protein sequence
Species Mouse MUC1 protein
Length 630
Mass (Da) 64539
Sequence Mouse MUC1 protein sequence
Species
Length
Mass (Da)
Sequence

MUC1 Protein Molecular Weight & PI

Mucin-1 precursor (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD227 antigen) [Contains: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)] Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 24-1255 Mucin-1.

Molecular weight (Da)

119671.32

Theoretical pI

6.96

MUC1 Protein Structure

Crystal structure of therapeutic mAB AR20.5 in complex with MUC1 peptide
Deposited
2016-09-01   Released:  2017-01-11
Deposition Author(s)
Brooks, C.L., Movahedin, M.
Organism(s)
Homo sapiens
Expression System
Mus musculus
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
1.9700 Å
R-Value Free
0.232
R-Value Work
0.221
5T6P From PDB

Human MUC1 protein Secondary structure

MUC1 Protein Interaction

Recombinant MUC1 Protein Feature

MUC1 Protein, Human, Recombinant

High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.

Recombinant MUC1 protein citations

Title
KL-6 regulated the expression of HGF, collagen and myofibroblast differentiation
Year
2013
Author
Xu, L;Yan, DR;Zhu, SL;Gu, J;Bian, W;Rong, ZH;Shen, C;
Journal
Eur Rev Med Pharmacol Sci
Title
Electrochemical Aptasensor for Determination of Mucin 1 by P-Aminophenol Redox Cycling
Year
2014
Author
Wang, Z;Xia, N;Shi, J;Li, S;Zhao, Y;Wang, H;
Journal
Analytical Letters
Title
Lactose-Functionalized Dendrimers Arbitrate the Interaction of Galectin-3/MUC1 Mediated Cancer Cellular Aggregation
Year
2014
Author
Michel, AK;Nangia-Makker, P;Raz, A;Cloninger, MJ;
Journal
Chembiochem
Title
Ultrasensitive Quantitation of Plasma Membrane Proteins via isRTA.
Year
2017
Author
Gao, T;Wang, B;Shi, L;Zhu, X;Xiang, Y;Anzai, JI;Li, G;
Journal
Anal. Chem.
Title
Amplified electrochemical detection of surface biomarker in breast cancer stem cell using self-assembled supramolecular nanocomposites
Year
2018
Author
Zhao, J;Tang, Y;Cao, Y;Chen, T;Chen, X;Mao, X;Yin, Y;Chen, G;
Journal
Electrochimica Acta
Title
Homogeneous electrochemical aptasensor for mucin 1 detection based on exonuclease I-assisted target recycling amplification strategy
Year
2018
Author
Lin, C;Zheng, H;Huang, Y;Chen, Z;Luo, F;Wang, J;Guo, L;Qiu, B;Lin, Z;Yang, H;
Journal
Biosens Bioelectron

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