p21/WAF1/CDKN1A Information: p21/WAF1/CDKN1A Protein, p21/WAF1/CDKN1A Antibody and p21/WAF1/CDKN1A Gene

p21/WAF1/CDKN1A Protein

p21/WAF1/CDKN1A protein function

May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739).

p21/WAF1/CDKN1A protein expression

Tissue specificity

Expressed in all adult tissues, with 5-fold lower levels observed in the brain.

Induction

Activated by p53/TP53, mezerein (antileukemic compound) and IFNB1. Repressed by HDAC1.

p21/WAF1/CDKN1A protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    164.00
  • Mass (KDa)
    18.00

p21/WAF1/CDKN1A Antibody

There are 1 p21/WAF1/CDKN1A antibodies which are validated in multiple tissues with various applications, including WB. There are 1 p21/WAF1/CDKN1A antibody for WB. Among all these p21/WAF1/CDKN1A antibodies, there are 1 anti-p21/WAF1/CDKN1A rabbit polyclonal antibodies . All the p21/WAF1/CDKN1A anbodies are produced in house and all are in stock. p21/WAF1/CDKN1A antibody customerized service is available.

p21/WAF1/CDKN1A Gene

CDKN1A cDNA / gene is a gene with protein product which located on 6p21.2. The CDKN1A gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. 181 organisms have orthologs with human gene CDKN1A.