p21/WAF1/CDKN1A Gene Sequence, Family, Fuction and Expression Information
p21/WAF1/CDKN1A cDNA / Gene Overview
CDKN1A cDNA / gene is a gene with protein product which located on 6p21.2. The CDKN1A gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. 181 organisms have orthologs with human gene CDKN1A.
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015]
p21/WAF1/CDKN1A cDNA / Gene Sequence
HSU03106 2121 bp mRNA linear PRI 25-FEB-1998
Human wild-type p53 activated fragment-1 (WAF1) mRNA, complete cds.
This sequence information is just for reference only.
p21/WAF1/CDKN1A cDNA / Gene Alias
p21Cip1 / Waf1
p21/WAF1/CDKN1A cDNA / Gene Expression
Ubiquitous expression in colon (RPKM 71.4), gall bladder (RPKM 68.8) and 24 other tissues