Protein S/PROS1 Gene Sequence, Family, Fuction and Expression Information

Protein S/PROS1 cDNA / Gene Overview

PROS1 gene / cDNA is a protein-coding gene which located on 3q11.1. The PROS1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.238 organisms have orthologs with human gene PROS1.

Protein S/PROS1 cDNA / Gene Function

This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]

Protein S/PROS1 cDNA / Gene Sequence

LOCUS
LOCUS NM_000313 3595 bp mRNA linear PRI 05-AUG-2018
DEFINITION
Homo sapiens protein S (PROS1), transcript variant 2, mRNA.
ACCESSION
NM_000313
VERSION
NM_000313.3

This sequence information is just for reference only.

Protein S/PROS1 Family & Reagents

Gene family

Protein S/PROS1 Gene family reagents (Gla domain containing)

Approved Symbol Reagent list
F10
F7
GAS6
PROC
Approved Symbol Reagent list
F2
F9
POSTN
TTR

Protein S/PROS1 cDNA / Gene Expression

Broad expression in liver (RPKM 79.4), heart (RPKM 44.6) and 21 other tissues