Protein S/PROS1 Gene Sequence, Family, Fuction and Expression Information
Protein S/PROS1 cDNA / Gene Overview
PROS1 gene / cDNA is a protein-coding gene which located on 3q11.1. The PROS1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.238 organisms have orthologs with human gene PROS1.
This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]
Protein S/PROS1 cDNA / Gene Sequence
LOCUS NM_000313 3595 bp mRNA linear PRI 05-AUG-2018
Homo sapiens protein S (PROS1), transcript variant 2, mRNA.
This sequence information is just for reference only.