TFF3 Gene Sequence, Family, Fuction and Expression Information

TFF3 cDNA / Gene Overview

TFF3 gene / cDNA is a protein-coding gene which located on 21q22.3. The TFF3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.79 organisms have orthologs with human gene TFF3.

TFF3 cDNA / Gene Function

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]

TFF3 cDNA / Gene Sequence

LOCUS NM_003226 1054 bp mRNA linear PRI 22-JUL-2018
Homo sapiens trefoil factor 3 (TFF3), mRNA.

This sequence information is just for reference only.

TFF3 cDNA / Gene Alias

  • HITF
  • ITF

TFF3 cDNA / Gene Expression

Biased expression in colon (RPKM 367.8), thyroid (RPKM 187.9) and 4 other tissues