TIGIT Protein Overview: Sequence, Structure, Function and Protein Interaction

TIGIT Protein Overview

TIGIT protein name

Recommended name
T-cell immunoreceptor with Ig and ITIM domains
DKFZp667A205, FLJ39873
Alternative name
V-set and immunoglobulin domain-containing protein 9 V-set and transmembrane domain-containing protein 3

TIGIT Protein Sequence

Species Human TIGIT protein
Length 244
Mass (Da) 26319
Sequence Human TIGIT protein sequence
Species Mouse TIGIT protein
Length 249
Mass (Da) 26959
Sequence Mouse TIGIT protein sequence
Mass (Da)

TIGIT Protein Molecular Weight & PI

T-cell immunoreceptor with Ig and ITIM domains precursor (V-set and immunoglobulin domain-containing protein 9) (V-set and transmembrane domain-containing protein 3) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 22-244 T-cell immunoreceptor with Ig and ITIM

Molecular weight (Da)


Theoretical pI


TIGIT Protein Structure

Crystal structure of the immunoreceptor TIGIT IgV domain
2011-10-27   Released:  2012-03-14
Deposition Author(s)
Yin, J.P., Stengel, K.F., Rouge, L., Bazan, J.F., Wiesmann, C.
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
2.6270 Å
R-Value Free
R-Value Work

Human TIGIT protein Secondary structure

TIGIT Protein Interaction

Recombinant TIGIT Protein Feature

TIGIT Protein, Human, Recombinant (ECD, His Tag)

High Purity
> 90 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
1. Measured by its ability to bind with human CD155-Fc (Cat:10109-H02H) in a functional ELISA. 2. Measured by its ability to bind with mouse PVR-Fch (Cat:50259-M03H) in a functional ELISA. 3. Using the Octet RED System, the affinity constant (Kd) of TIGIT Protein, Human, Recombinant (His Tag)(Cat: 10917-H08H) bound to MITG7192A was 0.1 nM.

Recombinant TIGIT protein citations

Self-assembled multivalent aptamer nanoparticles with potential CAR-like characteristics could activate T cells and inhibit melanoma growth both in vitro and in vivo
Bai, C;Gao, S;Hu, S;Liu, X;Li, H;Dong, J;Huang, A;Zhu, L;Zhou, P;Li, S;Shao, N;
Molecular Therapy - Oncolytics

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