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RPS6KA1  蛋白,抗体,试剂盒,cDNA克隆

RPS6KA1 相关研究领域

RPS6KA1 相关蛋白、抗体、cDNA基因、ELISA试剂盒

RPS6KA1 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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RPS6KA1 概述&蛋白信息

RPS6KA1 研究背景

催化活性: ATP + a protein = ADP + a phosphoprotein.
辅因子: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
酶调控: Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-573 in the C-terminal kinase domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-380, allowing binding of PDPK1, which in turn phosphorylates Ser-221 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD. {ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:9430688}.
亚单位结构: Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation. Interacts with ETV1/ER81 and FGFR1. {ECO:0000269|PubMed:12213813, ECO:0000269|PubMed:12832467, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:15342917, ECO:0000269|PubMed:17965187}.
结构域: 0
亚细胞定位: Nucleus. Cytoplasm.
组织特异性: 0
发育阶段: 0
诱导: 0
翻译后修饰: Activated by phosphorylation at Ser-221 by PDPK1. Autophosphorylated on Ser-380, as part of the activation process. May be phosphorylated at Thr-359 and Ser-363 by MAPK1/ERK2 and MAPK3/ERK1. {ECO:0000269|PubMed:9430688}.; N-terminal myristoylation results in an activated kinase in the absence of added growth factors.
相关疾病 : 0
相似的序列: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. {ECO:0000305}.; Contains 1 AGC-kinase C-terminal domain. {ECO:0000305}.; Contains 2 protein kinase domains. {ECO:0000255|PROSITE-ProRule:PRU00159}.
General information above from UniProt

RPS6KA1 别称

RPS6KA1 相关文献