Anti-SIRP alpha Antibody

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Anti-SIRP alpha Antibody (Rabbit Monoclonal 抗体) 产品信息

产品名称
Anti-SIRP alpha Antibody
经验证的应用
ELISA,FCM
交叉反应
Reacts with: Mouse
特异性
Mouse SIRP alpha
Has cross-reactivity in ELISA with
Human SIRPA
免疫原
Recombinant Mouse SIRP alpha / CD172a protein (Catalog#50956-M08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SIRP alpha / CD172a (Catalog#50956-M08H; BAA20376.1; Met1-Asn373).
来源
Monoclonal Rabbit IgG Clone #001
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-SIRP alpha Antibody (Rabbit Monoclonal 抗体) 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
FCM 1:25-1:100
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-SIRP alpha Antibody (Rabbit Monoclonal 抗体) 图片

Flow cytometric analysis of Mouse SIRPA(CD172a) expression on BABL/c bone marrow cells. Cells were stained with purified anti-Mouse SIRPA(CD172a), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Anti-SIRP alpha Antibody: 别称

Anti-AI835480 Antibody; Anti-Bit Antibody; Anti-CD172a Antibody; Anti-P84 Antibody; Anti-Ptpns1 Antibody; Anti-SHP-1 Antibody; Anti-SHPS-1 Antibody; Anti-SIRP Antibody

SIRP alpha 背景信息

Tyrosine-protein phosphatase non-receptor type substrate 1, also known as SHP substrate 1, Inhibitory receptor SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Macrophage fusion receptor, CD172 antigen-like family member A, SIRPA and CD172a, is a single-pass type I membrane protein which contains two Ig-like C1-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. SIRPA is ubiquitously expressed. It is highly expressed in brain and detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. It is also detected on myeloid cells, but not T-cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPA acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. It may play a key role in intracellular signaling during synaptogenesis and in synaptic function. SIRPA is involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. It mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation.
全称
signal-regulatory protein alpha
参考文献
  • Timms JF. et al., 1999, Curr Biol. 9: 927-30.
  • Stofega MR. et al., 2000, J Biol Chem. 275: 28222-9.
  • Liu T. et al., 2005, J Proteome Res. 4: 2070-80.
  • Wolf-Yadlin A. et al., 2007, Proc Natl Acad Sci. 104: 5860-5.
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