Anti-SIRP alpha Antibody (PE)

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Anti-SIRP alpha Antibody (PE) (Rabbit Monoclonal 抗体) 产品信息

产品名称
Anti-SIRP alpha Antibody (PE)
经验证的应用
FCM
交叉反应
Reacts with: Rat
特异性
Rat SIRP alpha
免疫原
Recombinant Rat SIRPA/SIRP alpha/CD172a Protein (Catalog#80270-R08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Rat SIRPA/SIRP alpha/CD172a (rR SIRPA/SIRP alpha/CD172a; Catalog#80270-R08H; P97710; Met1-Asn373) and conjugated with PE under optimum conditions, the unreacted PE was removed.
来源
Monoclonal Rabbit IgG Clone #103
纯化
Protein A
缓冲液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
偶联物
PE
浓度
2 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-SIRP alpha Antibody (PE) (Rabbit Monoclonal 抗体) 图片

Flow cytometric analysis of rat SIRPA(CD172a) expression on SD rat bone marrow cells. Cells were stained with PE-conjugated anti-rat SIRPA(CD172a). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

SIRP alpha 背景信息

Tyrosine-protein phosphatase non-receptor type substrate 1, also known as SHP substrate 1, Inhibitory receptor SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Macrophage fusion receptor, CD172 antigen-like family member A, SIRPA and CD172a, is a single-pass type I membrane protein which contains two Ig-like C1-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. SIRPA is ubiquitously expressed. It is highly expressed in brain and detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. It is also detected on myeloid cells, but not T-cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPA acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. It may play a key role in intracellular signaling during synaptogenesis and in synaptic function. SIRPA is involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. It mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation.
全称
signal-regulatory protein alpha
参考文献
  • Timms JF. et al., 1999, Curr Biol. 9: 927-30.
  • Stofega MR. et al., 2000, J Biol Chem. 275: 28222-9.
  • Liu T. et al., 2005, J Proteome Res. 4: 2070-80.
  • Wolf-Yadlin A. et al., 2007, Proc Natl Acad Sci. 104: 5860-5.
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