Anti-TNFR2 / TNFRSF1B Antibody

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Anti-TNFR2 / TNFRSF1B Antibody (Rabbit Monoclonal 抗体) 产品信息

产品名称
Anti-TNFR2 / TNFRSF1B Antibody
经验证的应用
ELISA(Cap)
交叉反应
Reacts with: Mouse
特异性
Mouse TNFR2 / TNFRSF1B
免疫原
Recombinant Mouse TNFR2 / TNFRSF1B / CD120b Protein (Catalog#50128-M08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse TNFR2 / TNFRSF1B / CD120b (rM TNFR2 / TNFRSF1B / CD120b; Catalog#50128-M08H; NP_035740.2; Met1-Gly258).
来源
Monoclonal Rabbit IgG Clone #204
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-TNFR2 / TNFRSF1B Antibody (Rabbit Monoclonal 抗体) 经验证的应用

Notes
ELISA(Cap): This antibody will detect Mouse TNFR2 / TNFRSF1B / CD120b in ELISA pair set (Catalog: # SEK50128). In a sandwich ELISA, it can be used as capture antibody when paired with (Catalog: # 50128-R340).
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-TNFR2 / TNFRSF1B Antibody: 别称

Anti-CD120b Antibody; Anti-p75 Antibody; Anti-TNF-alphaR2 Antibody; Anti-TNF-R-II Antibody; Anti-TNF-R2 Antibody; Anti-TNF-R75 Antibody; Anti-TNFalpha-R2 Antibody; Anti-TNFBR Antibody; Anti-Tnfr-1 Antibody; Anti-Tnfr2 Antibody; Anti-TNFR80 Antibody; Anti-TNFRII Antibody

TNFR2 / TNFRSF1B 背景信息

Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD12b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD12b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD12b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD12b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
全称
tumor necrosis factor receptor superfamily, member 1b
参考文献
  • Komata T, et al. (1999) Association of tumor necrosis factor receptor 2 (TNFR2) polymorphism with susceptibility to systemic lupus erythematosus. Tissue Antigens. 53(6): 527-33.
  • Tsuchiya N, et al. (2001) Analysis of the association of HLA-DRB1, TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test. Genes Immun. 2(6): 317-22.
  • Guo G, et al. (1999) Role of TNFR1 and TNFR2 receptors in tubulointerstitial fibrosis of obstructive nephropathy. Am J Physiol. 277(5): 766-72.
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