GITR cDNA ORF Clone in Cloning Vector, Human

GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.

• Cancer Immunotherapy
• Co-stimulatory Immune Checkpoint Targets
• Immune Checkpoint
• Immune Checkpoint Detection: ELISA Antibodies
• Immune Checkpoint Targets
• Immunotherapy
• Targeted Therapy

tumor necrosis factor receptor superfamily, member 18

• Immune Checkpoint>>Co-stimulatory Immune Checkpoint
• Immunology>>Innate Immunity>>Monocytes/Macrophages>>Co-stimulatory Molecules
• Immunology>>Inflammation / Inflammatory Mediator>>Inflammatory Cytokines & Chemoki and Receptors>>IL-12 Family
• Immunology>>Innate Immunity>>Cytokine>>Necrosis Factors
• Immunology>>Innate Immunity>>Cytokine>>TNF Superfamily>>Processes Regulated by TNF Superfamily Members>>Regulation of Natural Killer Cell Co-stimulation by TNF Superfamily Members
• Immunology>>Innate Immunity>>Cytokine>>TNF Superfamily>>Processes Regulated by TNF Superfamily Members>>Regulation of T Cell Co-stimulation by TNF Superfamily Members
• Immunology>>Adaptive Immunity>>Regulatory T Cells
• Immunology>>Innate Immunity>>Cytokine>>TNF
• Cardiovascular>>Angiogenesis>>Cytokine & Receptor>>Tumor Necrosis Factor (TNF) & Receptor>>TNF Receptor
• Immunology>>Innate Immunity>>Cytokine>>TNF Superfamily>>TNF Superfamily Receptors

• Kwon B, et al. (1999) Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. J Biol Chem. 274(10):6056-61.
• Nocentini G, et al. (1997) A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc Natl Acad Sci. 94(12): 6216-21.
• Baltz KM, et al. (2007) Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions. FASEB J. 21(10):2442-54.